Zeruesenay Desta Selected Research

Cytochrome P-450 CYP2D6 (CYP2D6)

1/2019	Drug-gene and drug-drug interactions associated with tramadol and codeine therapy in the INGENIOUS trial.
1/2018	CYP2D6 and Endoxifen in Tamoxifen Therapy: A Tribute to David A. Flockhart.
4/2010	A penalized mixture model approach in genotype/phenotype association analysis for quantitative phenotypes.
4/2010	Composite functional genetic and comedication CYP2D6 activity score in predicting tamoxifen drug exposure among breast cancer patients.
3/2010	Significant effect of polymorphisms in CYP2D6 and ABCC2 on clinical outcomes of adjuvant tamoxifen therapy for breast cancer patients.
9/2008	Cytochrome P450 2D6 and homeobox 13/interleukin-17B receptor: combining inherited and tumor gene markers for prediction of tamoxifen resistance.
1/2007	The impact of cytochrome P450 2D6 metabolism in women receiving adjuvant tamoxifen.
7/2006	Quantitative effect of CYP2D6 genotype and inhibitors on tamoxifen metabolism: implication for optimization of breast cancer treatment.
12/2005	Pharmacogenetics of tamoxifen biotransformation is associated with clinical outcomes of efficacy and hot flashes.
1/2005	CYP2D6 genotype, antidepressant use, and tamoxifen metabolism during adjuvant breast cancer treatment.

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Zeruesenay Desta Research Topics

Disease

31	Breast Neoplasms (Breast Cancer) 10/2022 - 07/2003
6	Neoplasms (Cancer) 01/2022 - 12/2005
5	Infections 01/2021 - 01/2002
5	Coronary Artery Disease (Coronary Atherosclerosis) 01/2015 - 01/2012
3	Inflammation (Inflammations) 01/2020 - 06/2010
3	Myocardial Infarction 10/2014 - 08/2010
3	Drug-Related Side Effects and Adverse Reactions 10/2014 - 01/2002
3	Hot Flashes 12/2005 - 12/2003
2	Pain (Aches) 10/2022 - 01/2019
2	Torsades de Pointes (Torsade de Pointes) 01/2021 - 10/2016
2	Tourette Syndrome (Tourette's Syndrome) 01/2020 - 04/2002
2	Hyperbilirubinemia 12/2014 - 07/2012
1	Opioid-Related Disorders (Opiate Addiction) 01/2021
1	Esophagitis 01/2021
1	Gastroesophageal Reflux (GERD) 01/2021
1	Duodenal Ulcer (Curling's Ulcer) 01/2021
1	Chronic Disease (Chronic Diseases) 01/2020
1	Hyperglycemia 01/2020
1	Obesity 01/2020
1	Anxiety Disorders (Anxiety Disorder) 01/2020
1	Type 2 Diabetes Mellitus (MODY) 01/2020
1	Tics (Tic) 01/2020
1	Pyruvate Dehydrogenase Complex Deficiency Disease 01/2020
1	Succinyl-CoA:3-oxoacid CoA transferase deficiency 01/2020
1	Fatigue 01/2020
1	Body Weight (Weight, Body) 11/2017
1	Cardiovascular Diseases (Cardiovascular Disease) 03/2016
1	Neutropenia 12/2014
1	Hypersensitivity (Allergy) 10/2014
1	Major Depressive Disorder (Major Depressive Disorders) 08/2014
1	Diabetes Mellitus 01/2013

Drug/Important Bio-Agent (IBA)

17	Tamoxifen FDA LinkGeneric 01/2018 - 07/2003
11	Aromatase InhibitorsIBA 10/2022 - 04/2010
11	Cytochrome P-450 CYP2D6 (CYP2D6)IBA 01/2019 - 12/2003
10	exemestane (Aromasin)FDA Link 10/2022 - 01/2011
10	Pharmaceutical PreparationsIBA 01/2022 - 05/2005
9	Letrozole (Femara)FDA LinkGeneric 10/2022 - 12/2012
6	Hormones (Hormone)IBA 10/2022 - 03/2010
6	efavirenz (Sustiva)FDA Link 01/2021 - 07/2003
6	EnzymesIBA 01/2020 - 01/2002
6	Estrogens (Estrogen)FDA Link 01/2020 - 05/2005
6	Anastrozole (Arimidex)FDA LinkGeneric 01/2020 - 04/2010
5	Selective Serotonin Reuptake Inhibitors (Serotonin Reuptake Inhibitors)IBA 01/2020 - 04/2002
5	Estrogen ReceptorsIBA 01/2020 - 05/2005
5	4-hydroxy-N-desmethyltamoxifenIBA 11/2017 - 05/2005
5	Clopidogrel (Plavix)FDA Link 01/2015 - 01/2012
4	Antidepressive Agents (Antidepressants)IBA 01/2021 - 04/2002
3	LipidsIBA 01/2020 - 12/2012
3	Aspirin (Acetylsalicylic Acid)FDA LinkGeneric 01/2015 - 01/2013
2	AcidsIBA 01/2021 - 01/2002
2	Bupropion (Wellbutrin)FDA LinkGeneric 01/2021 - 01/2020
2	Methadone (Dolophine)FDA LinkGeneric 01/2021 - 01/2021
2	Aromatase (CYP19)IBA 01/2020 - 01/2012
2	Escitalopram FDA Link 01/2020 - 08/2014
2	Pimozide (Orap)FDA Link 01/2020 - 04/2002
2	Cytochrome P-450 CYP2C9IBA 11/2017 - 01/2005
2	Atazanavir Sulfate (Reyataz)FDA Link 12/2014 - 07/2012
2	Pentoxifylline (Trental)FDA LinkGeneric 01/2013 - 06/2010
2	Cytochrome P-450 Enzyme System (Cytochrome P450)IBA 12/2005 - 07/2004
2	Cytochrome P-450 CYP3AIBA 12/2005 - 01/2005
2	Cytochrome P-450 CYP2C19IBA 07/2004 - 01/2002
2	Cytochrome P-450 CYP2B6 (CYP2B6)IBA 07/2004 - 07/2003
1	taxaneIBA 10/2022
1	Analgesics (Analgesic Drugs)IBA 01/2021
1	Ketamine FDA LinkGeneric 01/2021
1	Proton Pump InhibitorsIBA 01/2021
1	Glucose (Dextrose)FDA LinkGeneric 01/2020
1	Proteins (Proteins, Gene)FDA Link 01/2020
1	Oxidoreductases (Dehydrogenase)IBA 01/2020
1	CarbohydratesIBA 01/2020
1	Dopamine (Intropin)FDA LinkGeneric 01/2020
1	Estradiol (Delestrogen)FDA LinkGeneric 01/2020
1	Estrone FDA Link 01/2020
1	Norepinephrine (Noradrenaline)FDA LinkGeneric 01/2020
1	KetonesIBA 01/2020
1	LigandsIBA 01/2020
1	Biological ProductsIBA 01/2020
1	Pyruvic Acid (Pyruvate)IBA 01/2020
1	Reverse Transcriptase InhibitorsIBA 10/2019
1	2- cyclohexylidenhydrazo- 4- phenyl- thiazoleIBA 01/2018
1	Cytochrome P-450 CYP2C8IBA 11/2017
1	IGF-I-IGFBP-3 complex FDA Link 11/2017
1	Adenosine Diphosphate (ADP)IBA 01/2015
1	Factor XIIIaIBA 01/2015
1	Protease Inhibitors (Protease Inhibitor)IBA 12/2014
1	Hemoglobins (Hemoglobin)IBA 12/2014
1	DNA Transposable Elements (Element, IS)IBA 10/2014
1	FibrinIBA 10/2014
1	Factor XIII (Coagulation Factor XIII)IBA 10/2014
1	Rifampin (Rifampicin)FDA LinkGeneric 10/2014
1	Citalopram FDA LinkGeneric 08/2014
1	Indoleamine-Pyrrole 2,3,-Dioxygenase (Indoleamine 2,3 Dioxygenase)IBA 04/2013
1	CytokinesIBA 04/2013
1	Alprostadil (Muse)FDA LinkGeneric 01/2013
1	Nitroglycerin (Dynamite)FDA LinkGeneric 01/2013

Therapy/Procedure

18	Therapeutics 01/2020 - 07/2003
1	Time-to-Treatment 10/2022
1	Precision Medicine 01/2022
1	Radiotherapy 01/2020
1	Drug Therapy (Chemotherapy) 01/2020